Upstream signal transduction of NF-kB activation

TNFa-stimulated activation of genes downstream of NF-kB

Xiang Wang*, Kun Zhu*, Shangze Li, Yifang Liao, Runlei Du, Xiaodong Zhang, Hong-Bing Shu, An-Yuan Guo, Lianyun Li and Min Wu College of Life Sciences, Wuhan University, Wuhan, Hubei430072 China Hubei Enteropathy Key Laboratory, Wuhan, Hubei, 430072 China Hubei Bioinformatics & Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology...

The IKK Complex, a Central Regulator of NF-kB Activation

The IKK kinase complex is the core element of the NF-kB cascade. It is essentially made of two kinases (IKKa and IKKb) and a regulatory subunit, NEMO/IKKg. Additional components may exist, transiently or permanently, but their characterization is still unsure. In addition, it has been shown that two separate NF-kB pathways exist, depending on the activating signal and the cell type, the canonic...

Cutting Edge: TCR Ligation Triggers Digital Activation of NF-kB

Constitutive Activation of NF-kB Impairs Osteogenesis and Skeletal Development

Introduction: Bone is constantly remodeled by precise regulatory mechanisms that coordinate bone formation and bone resorption. Overall bone homeostasis is determined by the net balance between bone formation by osteoblasts and bone resorption by osteoclasts. In this regard, it is well-known that pathologic conditions impair bone homeostasis. Specifically, numerous reports indicate that localiz...

Diisononyl phthalate aggravates allergic dermatitis by activation of NF-kB

Several epidemiological studies have suggested a possible link between exposure to Diisononyl phthalate (DINP) and the development of allergies. These findings remain controversial since there is insufficient scientific evidence to assess the ability of DINP to influence allergic immune responses. In addition, the mechanisms behind DINP-caused allergic diseases have not been fully elucidated. I...